The Quarantine Reserve was attached to the Hexham Estate (originally known as Cluthaville) located between the Hexham (The House) and Parramatta River's Chicken and Hen Bay. Giving the house sweeping views of
its gardens and down to the river. There is no known evidence how the land was originally
added to the grounds of Hexham.
Taronga Zoological Park outgrew
its Moore Park site in 1912, and the Quarantine Station at Bradley's Head had to be relocated to make way for the Zoo Site. Hexham/Cluthaville's added ground was short-lived. Since it was a water front property with road access, the Commonwealth Government seen it fit
to acquire the land for the displaced Quarantine Station.
The Quarantine Station occupied the site between 1917 and 1980 to house and clear disease-free imported animals before they were handed over to their owners.
The Quarantine Station was developed between 1917 and 1930. The station consisted of